Bacterial Vaginosis – Why Antimicrobial Treatments Is Preferred to Sulfa Antibiotics
Sulfonylmethane (SMM) is a class of antimicrobial drugs known as sulfa antibiotics or sulfonamides
Primary antimicrobial sulfonamides that were originally developed in the 1950s are synthetic sulfonamide antibiotics. Today's sulfa antibiotics are different from what they were originally developed and include sulfonamide derivatives as well as sulfa antibiotics and sulfamethoxazole derivatives. The class of sulfonyl sulfates includes the best known sulfasalazine antibiotics and their derivatives.
Sulfonic acid and sulfur compounds can only be applied to bacteria through a method known as sulfolysis. In sulfolysis, an organic compound (such as a carbohydrate) combines with an inorganic compound such as an acid to form a compound that is toxic to bacteria. The class of sulfonyl sulfates includes sulfatidylates, carbamic acids and sulfur-containing sulfate compounds. These sulfur compounds have been shown to be very effective against certain types of bacterial infections, including Streptococcus pneumoniae, Staphylococcus aureus, and E. coli. Several of the sulfur compounds have also been shown to be effective against certain types of fungi.
Sulfate antibiotics and sulfamethoxazole derivatives are known to be more effective against certain strains of Streptococcus than others. Some of these antibiotics are reported to be as effective as prescription antibiotics in fighting infections caused by this type of bacteria. Most clinical studies comparing sulfamethoxazole derivatives with sulfasalazine antibiotics have concluded that sulfur compounds have the same bactericidal effect as sulfasalazine.
Other sulfa antibiotics that are commonly used to treat sore throats and ear infections, such as amoxicillin, penicillin, and tetracycline, are commonly used in combination with sulfur compounds. One of these antibiotics, tetracycline, has been used as "strenghin", which is a compound that acts as a precursor to sulfate antibiotics. Sulfate antibiotics kill microorganisms without affecting their DNA.
Another group of sulfite antibiotics that are often used in conjunction with sulfa antibiotics are some of the sulfasalazine derivatives. Some of these include: sulfamycin, clavulanate, penicillin, cephalexin, chloramphenicol and colistin.
Sulfisulphide antibiotics are a special class of antibiotic, which includes: Miconazole, Tioconazole, Methylmethacrylate and Miconzole. These antibiotics are used to treat anaerobic gram positive and aerobes. They work by reducing the ability of these microorganisms to metabolize carbohydrates and to form glycogen. Glycogen is a type of carbohydrate found in the cell walls of certain aerobic cells. Because glycogen is a negative glucose-releasing polymer, it serves to store excess glucose from the diet.
Glycogen is broken down to provide energy for respiration and to promote the breakdown of lipids. The sulfite antibiotics prevent these microorganisms from breaking down glycogen by binding to it and preventing glycan synthesis and thereby reducing its activity. These antibiotics are sometimes referred to as glycogen suppressants.
Some of the sulfasalazine antibiotics that are commonly used in combination with sulfasalazine antibiotics include: Miconazole, Penicillin, Ketoconazole and Doxycycline. These antibiotics have been used to treat a variety of bacteria, fungi and parasites including E. coli, Staphylococcus, Enterococcus and Propionibacterium. Sulfase antibiotics have been known to be toxic to anaerobic bacteria. This occurs when the sulfate is unable to be metabolized by these microorganisms and can build up in the blood stream.
Antimicrobial compounds like glycogen inhibitors are also commonly used in combination with sulfa antibiotics. They reduce the ability of some bacteria to metabolize glycogen and cause them to die. It has also been shown that sulfasalazine antibiotics kill certain types of bacteria but not others. The sulfasalazine component of sulfadoxine is not particularly toxic to most bacteria.
Sulfasalazine antibiotics are not usually used alone in order to cure infections. Instead, they are often used in combination with other antibiotics such as tetracycline and erythromycin. This is because they are less likely to produce any adverse reactions in patients taking them. The use of combination therapy is more common with children than adults because they are more vulnerable to infections. sulfonamides.
Although sulfasalazine antibiotics are very effective against bacterial vaginosis, some people have reported an unpleasant odor, itching and burning of the vagina after taking them. The treatment may also cause serious side effects in some patients.